The School was opened on 3rd February, 1949 with the arrival of 50 students and its formal opening ceremony was attended by many dignitaries, including
The Asantehene, Otumfuo Osei-Agyemang Prempeh II, Major C. O. Butler, Church Leaders, Chiefs and members of the Kumasi Traditional Council.
The Asantehene maintained a keen interest in the school and was a frequent attendant at the School’s Speech and Prize-Giving Days.
The College has been under the watch of 10 Headmasters since it was founded some 62 years ago. The first Headmaster, Rev. S. N. Pearson in his four year term set the trail blazing by making discipline and academic work his principal occupation. He also started to replace the old buildings of the former 52nd military Hospital. His successors continued to build on the solid foundation laid.
Special mention is made of Dr. T. A. Osae, first African headmaster who brought the work of his predecessors to fruition and built on it.
Under him Prempeh was placed on a high pedestal, beating key schools academically for ten consecutive years, producing more students for medical schools than any other School and becoming Champions in Athletics. Old Students (Amanfoﬤ) have instituted an annual Pearson – Osae Memorial Lectures in honour of these main pivots of Prempeh College’s success story. The invaluable contributions of all other headmasters, which cannot be recounted for time and space, has kept Prempeh in the limelight as one of the top second cycle institutions in the country.
Today the success story of Prempeh College has made it a school of choice for boys across the country. The vision and dreams of the Monarch and the others have become a reality and today alumni of the school are serving in many positions of responsibility in and outside the country. They have distinguished themselves as academics, doctors, lawyers, teachers, engineers, architects, traditional rulers and as officers in the security services. In the political arena, the immediate past President of the Republic of Ghana, Mr. J. A. Kufour is an Amanfoכ.
The school looks into the future with hope and will continue to make the sky the limit.