Mawuli School was established on February 24th, 1950 at Ho as a result of joint efforts by the then government of the Gold Coast, now Ghana and the Evangelical Presbyterian Church. It happened to be the first government assisted secondary school in the Volta Region. The Colonial British Government administering the mandated trust territory of Togo land was accused of neglect of the territory educationally. The fact that the accusation had reached the United Nations caused the Governor of the Colonial Administration himself to be keenly interested in seeing to it that something was done before the visit of the UN Commission to the colony to ascertain the facts for itself. This was what led to the birth of Mawuli School at Ho. Since the E.P Church was also exploring the possibility of establishing a Secondary School, the Colonial Government and the Church went ahead with plans to get the school started to solve the political problem. Rev. Prof. C. G. Baeta of Blessed memory, who was the Synod Clerk of the E. P Church, Ghana in 1948 -1949, was mandated by the church to find a science graduate reverend minister to head the school because the church wanted the school to have a strong science base and sound moral upbringing.